About
WeFa.st is organized by HVMN, a nootropics and biohacking company. Intermittent fasting is one of the most compelling methods to enhance human longevity and other performance metrics, and is now a core part of our company culture.
More and more people in our community were interested in learning more and joining us, and so WeFast was born. WeFast now serves as a hub and community for people around the world interesting in intermittent fasting and biohacking.
Disclaimer: Don’t fast if you have a history of eating disorders or are underweight, pregnant or nursing mother, a child, or have any medical condition that would make fasting inappropriate as a tool. Consult your doctor before starting any new routine. We’re an open discussion community around the science and practice of healthy fasting, and nothing here is considered medical advice or guidance.
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Media
[TEDx Video] Why fasting bolsters brain power by Mark Mattson
Mark Mattson is the current Chief of the Laboratory of Neurosciences at the National Institute on Aging. He is also a professor of Neuroscience at The Johns Hopkins University. Mattson is one of the foremost researchers in the area of cellular and molecular mechanisms underlying neurodegenerative disorders such as Alzheimer’s Disease, Parkinson’s Disease, and amyotrophic lateral sclerosis.
Want to Hack Your Body? This Startup Says Its Pills Will Help
Geoffrey Woo and Michael Brandt founded the start-up HVMN that sells so-called “nootropics,” pills designed to enhance memory, cognition, and mental stamina. HVMNвЂs mission is to improve the way we function on a daily basis. The company sees a market in people who want an extra edge but don’t want prescription drugs like Adderall. “In the office of the future, people will get to work, sit down, and pop a pill to help them focus better,” says Brandt, HVMNвЂs chief operating officer. But when that future will arrive is unclear. Bloomberg BusinessweekвЂs Caroline Winter visited HVMN’s officein California.
Getting Started
There are various fasting regimens. WeFast pioneered the Monk Fast (36-hour water fast) as a sustainable and efficient fast that targets our desired performance and longevity benefits.
The Monk Fast Overview
The Monk Fast is a continuous 36 hour water fast. This means you can and should drink plenty of water and other 0-calorie liquids to stay hydrated.
- Day 1: End your first day (e.g. Monday) with a typical dinner.
- Day 2: Fast the entire day (e.g. Tuesday).
- Day 3: Break fast on Day 3 (e.g. Wednesday).
The liver has ~100g of glycogen stores, and this is typically depleted in 16-24 hours. Thus, the body enters a period of 12-20 hours of ketosis. This regimen is easy to sustain because it only requires 2 days of discipline rather than a lifetime of caloric restriction.
For those who are focused on performance-enhancement and not weight-loss, a lot of WeFast members have found that after an initial adjustment period, there’s no additional weight or muscle loss.
How Fasting Works
During a fast, the body stops receiving external nutrients from food consumption. But the body must have energy to function. Fortunately, our bodies have plenty of internal energy stores. This is particularly the case in modern society where over 2/3 of Americans are overweight or obese.
Glycogen / Glycolysis:
- Glycolysis is the body using glucose or sugar as an energy source.
- Glycogen is how the body stores carbohydrates which come from foods like bread, cereal, noodles, etc. The liver has ~100g of glycogen stores, and this is typically depleted in 16-24 hours.
- Once there are no more carbohydrates from food consumption or glycogen, the body switches from glycolysis to ketosis.
Ketone bodies / Ketosis:
- Ketosis is the body using ketone bodies, which come from fat, as an energy source.
- Ketosis is considered an important indicator of autophagy — the breaking down of senescent or aged cells. The accelerated renewal of cells is associated with health and longevity benefits.
From an evolutionary biology perspective, fasting mimics our ancestral feast and famine cycles. When there’s no food, the body perks up into a higher “hunter-mode” gear to more effectively hunt and forage for sustenance. This may be why neuron growth is accelerated during a fast.
Tips For Your First Fast
Your choice of days on which to fast is an important decision. Choosing days that don’t interfere with social obligations makes it easier to stick to the fasting regimen. Therefore, we recommend a Monday dinner to Wednesday breakfast Monk Fast as most social meals happen towards the end of the week and weekends.
Drink plenty of water. A lot of our water consumption is in the food we eat, so be prepared to drink more water than usual.
Stay warm. A lot of WeFast members have felt chillier than normal on fast days. This means the fast is working as your body is starting to conserve energy.
To make the fast more palatable, we recommend drinking zero-calorie coffee or tea. Nootropics with caffeine (e.g. ) can be helpful as well to maintain productivity and focus through a fast. Caffeine also serves as a mild appetite suppressant.
It is common to feel hunger pangs. This occurs because your mind is accustomed to eating as a habit. Avoiding succumbing to eating is a mental challenge, and the best way to avoid them is to keep yourself busy.
Nootropics with caffeine (e.g. Sprint by HVMN) can be helpful as well to maintain productivity and focus through a fast. Caffeine also serves as a mild appetite suppressant.
Breaking Fast
When you wake up on Day 3, your fast is over. Before breaking the fast, we recommend that you drink some water.
When breaking your fast, note that your stomach has shrunk over the 36 hours, so eat light and slowly for this breakfast. Avoid foods that are hard to digest like beans and other legumes and note that alcohol and other cognition-modulating compounds can affect your body more heavily than normal.
Science
Effects on Longevity
Research has suggested that intermittent fasting may have a positive effect on
longevity. The research ranges from retrospective studies on human populations with
high longevity, to prospective studies involving biomarker analysis before and after
periods of fasting or caloric restriction.(Learn more)
Effects on Metabolism
Research has suggested that intermittent fasting may have a positive effect on
metabolism. The research ranges from animal studies on insulin resistence and
obesity biomarkers, to prospective human studies involving biomarker analysis before
and after periods of fasting or caloric restriction.(Learn more)
Effects on Immunity
Research has suggested that intermittent fasting may have a positive effect on
immunity and inflammation. This area has been studied in animals and humans with
respective to relevant biomarkers.()
